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Therapy Name | HSV-Tk |
Synonyms | |
Therapy Description |
HSV-Tk (Nalotimagene carmaleucel) is a gene therapy encoding the herpes simplex virus thymidine kinase (HSV-tk), which when introduced together with ganciclovir (GCV), converts GCV to a potent cytotoxic drug that disrupts DNA replication and leads to cell death (PMID: 17327829). |