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| Drug Name | HSV-Tk |
| Trade Name | |
| Synonyms | Nalotimagene carmaleucel |
| Drug Descriptions |
HSV-Tk (Nalotimagene carmaleucel) is a gene therapy encoding the herpes simplex virus thymidine kinase (HSV-tk), which when introduced together with ganciclovir (GCV), converts GCV to a potent cytotoxic drug that disrupts DNA replication and leads to cell death (PMID: 17327829). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Bicalutamide + HSV-Tk + Leuprolide + Valacyclovir | Bicalutamide HSV-Tk Leuprolide Valacyclovir | 0 | 1 |
| HSV-Tk | HSV-Tk | 0 | 1 |
| HSV-Tk + Valacyclovir | HSV-Tk Valacyclovir | 0 | 1 |
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