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Therapy Name Lifileucel
Synonyms
Therapy Description

LN-144 (lifileucel) is a preparation of tumor infiltrating lymphocytes isolated and expanded from patient tumor tissue, which may demonstrate enhanced anti-tumor immune activity when re-introduced into patients (Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 3045-3045).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Lifileucel Amtagvi LN-144|LN144|LN 144 Amtagvi (lifileucel) is a preparation of tumor-infiltrating lymphocytes isolated and expanded from patient tumor tissue, which may demonstrate enhanced anti-tumor immune activity when re-introduced into patients (PMID: 33979178). Amtagvi (lifileucel) is FDA-approved for use in patients with previously treated unresectable or metastatic melanoma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06566092 Phase I Lifileucel LN-145 Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants Recruiting USA 0
NCT05640193 Phase I Lifileucel Pilot Trial of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Patients With Asymptomatic Melanoma Brain Metastases Active, not recruiting USA 0
NCT05607095 Phase I Lifileucel Pilot Trial of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Patients With Metastatic Uveal Melanoma Recruiting USA 0
NCT06190249 Phase I Cyclophosphamide + Fludarabine Lifileucel Pembrolizumab Aldesleukin Mesna Efficacy & Safety for LN144 With Pembrolizumab With High Risk Stage IIIb-dResectable Melanoma Suspended USA 0
NCT02360579 Phase II Lifileucel Study of LN-144, Autologous Tumor Infiltrating Lymphocytes, in the Treatment of Patients With Metastatic Melanoma (LN-144) Active, not recruiting USA | ITA | HUN | GBR | FRA | ESP | DEU | CHE 0
NCT05398640 Expanded access Lifileucel Expanded Access Program of Lifileucel (LN-144) in Patients With Unresectable or Metastatic Melanoma Available USA 0
NCT06151847 Phase II Cyclophosphamide + Fludarabine Lifileucel Aldesleukin Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanoma Recruiting USA 0


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