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Therapy Name Atovaquone + Cytarabine + Daunorubicin + Gemtuzumab ozogamicin
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Atovaquone Mepron Mepron (atovaquone) is an anti-malarial drug typically used to treat pneumocystis pneumonia and toxoplasmosis, however, may also have an effect on cancer stem cells via the Warburg effect, potentially resulting in decreased cell proliferation and apoptosis (PMID: 27136895).
Cytarabine Cytosar-U Ara-C Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309).
Daunorubicin Cerubidine Rubidomycin|daunomycin hydrochloride|rubomycin C|Acetyladriamycin Chemotherapy - Anthracycline 13 Cerubidine (daunorubicin) is an anthracycline, which inhibits DNA replication and repair. Cerubidine (daunorubicin) is FDA approved for AML and MLL (FDA.gov).
Gemtuzumab ozogamicin Mylotarg gemtuzumab|CDP-771|CMA-676|WAY-CMA-676 CD33 Antibody 15 Mylotarg (gemtuzumab ozogamicin) is an antibody-drug conjugate comprising an anti-CD33 antibody linked to the cytotoxic agent calicheamicin, which results in DNA damage in CD33-expressing tumor cells (PMID: 28607471). Mylotarg (gemtuzumab ozogamicin) is FDA approved for newly-diagnosed CD33-positive acute myeloid leukemia (AML) in adult and pediatric patients 1 month and older, and in relapsed or refractory CD33-positive AML in adult and pediatric patients 2 years and older (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03568994 Phase I Atovaquone + Cytarabine + Daunorubicin + Etoposide Atovaquone + Cytarabine + Daunorubicin + Gemtuzumab ozogamicin Atovaquone (Mepron) Combined With Conventional Chemotherapy for de Novo Acute Myeloid Leukemia (AML) Active, not recruiting USA 0


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