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Therapy Detail

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Therapy Name ARX-788
Synonyms
Therapy Description

ARX-788 is an antibody-drug conjugate (ADC) comprising a dolastatin analog and an antibody specific to ERBB2 (HER2), which may result in cell death and tumor regression (Cancer Res 2015;75(15 Suppl):Abstract nr 639, PMID: 30841523, PMID: 32669315).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ARX-788 ARX788|ARX 788 HER2 (ERBB2) Antibody 77 HER2 (ERBB2) Antibody-Drug Conjugate 33 ARX-788 is an antibody-drug conjugate (ADC) comprising a dolastatin analog and an antibody specific to ERBB2 (HER2), which may result in cell death and tumor regression (Cancer Res 2015;75(15 Suppl):Abstract nr 639, PMID: 30841523, PMID: 32669315).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03255070 Phase I ARX-788 A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01) Completed USA | AUS 0
NCT06224673 Phase II ARX-788 ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer Not yet recruiting USA 0
NCT05041972 Phase II ARX-788 ARX788 in Selected HER2-mutated or HER2-amplified/Overexpressed Solid Tumors (ACE-Pan Tumor-02) Withdrawn USA 0
NCT04829604 Phase II ARX-788 ARX788 in HER2-positive, Metastatic Breast Cancer Subjects (ACE-Breast-03) Recruiting USA | FRA | AUS 1


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