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Therapy Name | AO-176 |
Synonyms | |
Therapy Description |
AO-176 is an antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells and may also stimulate cytotoxic T-cells (PMID: 29873856, PMID: 31879362). |