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Drug Name | AO-176 |
Trade Name | |
Synonyms | AO176|AO 176 |
Drug Descriptions |
AO-176 is an antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells and may also stimulate cytotoxic T-cells (PMID: 29873856, PMID: 31879362). |
DrugClasses | CD47 Antibody 31 Immune Checkpoint Inhibitor 149 |
CAS Registry Number | NA |
NCIT ID | C159600 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AO-176 | AO-176 | 0 | 2 |
AO-176 + Bortezomib + Dexamethasone | AO-176 Bortezomib Dexamethasone | 0 | 1 |
AO-176 + Dexamethasone | AO-176 Dexamethasone | 0 | 1 |