Therapy Detail
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| Therapy Name | Farletuzumab ecteribulin |
| Synonyms | |
| Therapy Description |
Farletuzumab ecteribulin (MORAb-202) is an anti-folate receptor alpha (FRA) antibody (farletuzumab) in conjugation with eribulin, which may lead to cytotoxic killing of FRA-positive tumors (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B115, PMID: 30262588). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Farletuzumab ecteribulin | MORAb 202|MORAb202|MORAb-202 | FOLR1-targeted Therapy 24 | Farletuzumab ecteribulin (MORAb-202) is an anti-folate receptor alpha (FRA) antibody (farletuzumab) in conjugation with eribulin, which may lead to cytotoxic killing of FRA-positive tumors (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B115, PMID: 30262588). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04300556 | Phase Ib/II | Dexamethasone + Farletuzumab ecteribulin Farletuzumab ecteribulin + Prednisolone Farletuzumab ecteribulin + Prednisone Farletuzumab ecteribulin + Lenvatinib Farletuzumab ecteribulin | A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRalph)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types | Recruiting | USA | GBR | FRA | ESP | 1 |
| NCT05577715 | Phase II | Farletuzumab ecteribulin | A Study of MORAb-202 in Participants With Previously Treated Metastatic Non-Small Cell Lung Cancer (NSCLC) Adenocarcinoma (AC) | Terminated | USA | FRA | ESP | BEL | AUS | 1 |
| NCT05613088 | Phase II | Paclitaxel + Pegylated liposomal doxorubicin + Topotecan Farletuzumab ecteribulin | A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer | Completed | USA | ITA | ISR | ESP | BEL | AUS | 3 |
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