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Therapy Name Ningetinib
Synonyms
Therapy Description

Ningetinib (CT053PTSA) inhibits MET, VEGFR2, AXL, and FLT3, which potentially reduces tumor cell growth (PMID: 36341335, PMID: 38978049).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ningetinib CT053PTSA|CT-053-PTSA AXL Inhibitor 30 FLT3 Inhibitor 69 MET Inhibitor 59 VEGFR2 Inhibitor 37 Ningetinib (CT053PTSA) inhibits MET, VEGFR2, AXL, and FLT3, which potentially reduces tumor cell growth (PMID: 36341335, PMID: 38978049).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 D835V hematologic cancer sensitive Ningetinib Preclinical - Cell culture Actionable In a preclinical study, Ningetinib (CT053PTSA) inhibited Flt3 downstream signaling and viability in a cell line expressing a FLT3-ITD and FLT3 D835V in culture (PMID: 38978049). 38978049
FLT3 exon 14 ins acute myeloid leukemia sensitive Ningetinib Preclinical - Cell line xenograft Actionable In a preclinical study, Ningetinib (CT053PTSA) induced cell cycle arrest and apoptosis and inhibited Flt3 downstream signaling and viability in acute myeloid leukemia cell lines harboring a FLT3-ITD, inhibited Flt3 downstream signaling and proliferation in patient-derived cells in culture, and decreased leukemic burden in a cell line xenograft model (PMID: 38978049). 38978049
FLT3 exon 14 ins FLT3 D835Y hematologic cancer sensitive Ningetinib Preclinical - Cell culture Actionable In a preclinical study, Ningetinib (CT053PTSA) inhibited Flt3 downstream signaling and viability in a cell line expressing a FLT3-ITD and FLT3 D835Y in culture (PMID: 38978049). 38978049
FLT3 exon 14 ins FLT3 N676D hematologic cancer sensitive Ningetinib Preclinical - Cell culture Actionable In a preclinical study, Ningetinib (CT053PTSA) inhibited viability in a cell line expressing a FLT3-ITD and FLT3 N676D in culture (PMID: 38978049). 38978049
FLT3 exon 14 ins hematologic cancer sensitive Ningetinib Preclinical Actionable In a preclinical study, Ningetinib (CT053PTSA) inhibited Flt3 downstream signaling and viability in a cell line expressing a FLT3-ITD in culture and decreased leukemic burden in a mouse model (PMID: 38978049). 38978049
FLT3 exon 14 ins FLT3 Y842C hematologic cancer sensitive Ningetinib Preclinical - Cell culture Actionable In a preclinical study, Ningetinib (CT053PTSA) inhibited Flt3 downstream signaling and viability in a cell line expressing a FLT3-ITD and FLT3 Y842C in culture (PMID: 38978049). 38978049
FLT3 exon 14 ins FLT3 F691L hematologic cancer sensitive Ningetinib Preclinical Actionable In a preclinical study, Ningetinib (CT053PTSA) inhibited Flt3 downstream signaling and viability in a cell line expressing a FLT3-ITD and FLT3 F691L in culture and decreased leukemic burden and prolonged survival in a mouse model (PMID: 38978049). 38978049
FLT3 exon 14 ins FLT3 F691L acute myeloid leukemia sensitive Ningetinib Preclinical - Cell line xenograft Actionable In a preclinical study, Ningetinib (CT053PTSA) decreased leukemic burden in a cell line xenograft model of acute myeloid leukemia harboring a FLT3-ITD and expressing FLT3 F691L (PMID: 38978049). 38978049

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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