Therapy Detail
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| Therapy Name | Seclidemstat |
| Synonyms | |
| Therapy Description |
Seclidemstat (SP-2577) is a reversible LSD1 (KDM1A) inhibitor that inhibits transcriptional function of EWS/ETS fusions, leading to anti-tumor activity (AACR Annual Meeting 2019, Abstract CT-109, PMID: 32649682). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Seclidemstat | SP2577|SP 2577|SP-2577 | KDM1A Inhibitor 15 | Seclidemstat (SP-2577) is a reversible LSD1 (KDM1A) inhibitor that inhibits transcriptional function of EWS/ETS fusions, leading to anti-tumor activity (AACR Annual Meeting 2019, Abstract CT-109, PMID: 32649682). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03895684 | Phase I | Seclidemstat | Phase 1 Trial of the LSD1 Inhibitor SP-2577 (Seclidemstat) in Patients With Advanced Solid Tumors | Completed | USA | 0 |
| NCT03600649 | Phase I | Seclidemstat | Clinical Trial of SP-2577 in Patients With Relapsed or Refractory Ewing Sarcoma | Active, not recruiting | USA | 0 |
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