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Therapy Name | CLR 131 |
Synonyms | |
Therapy Description |
CLR 131 is a compound that contains specific phospholipid ethers, CLR 1404, linked to the radioisotope iodine I 131, which when taken up by cancer cells induces cytotoxicity (PMID: 32483729). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
CLR 131 | CLR 1404 I-131 | CLR 131 is a compound that contains specific phospholipid ethers, CLR 1404, linked to the radioisotope iodine I 131, which when taken up by cancer cells induces cytotoxicity (PMID: 32483729). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT03478462 | Phase I | CLR 131 | Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Brain Cancer, Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma | Active, not recruiting | USA | CAN | AUS | 0 |
NCT05610891 | Phase I | CLR 131 | Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG | Recruiting | USA | CAN | 0 |
NCT04105543 | Phase I | CLR 131 | CLR 131 Combined With Radiation for Head and Neck Cancer | Completed | USA | 0 |