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| Therapy Name | IMGN632 |
| Synonyms | |
| Therapy Description |
IMGN632 is an antibody-drug conjugate (ADC) comprising an anti-CD123 (IL3RA) antibody linked to a DNA alkylating indolinobenzodiazepine pseudodimer, which may induce cytotoxicity in cells expressing CD123 (IL3RA) (PMID: 29661755, PMID: 30361418). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| IMGN632 | IMGN 632|IMGN-632 | IMGN632 is an antibody-drug conjugate (ADC) comprising an anti-CD123 (IL3RA) antibody linked to a DNA alkylating indolinobenzodiazepine pseudodimer, which may induce cytotoxicity in cells expressing CD123 (IL3RA) (PMID: 29661755, PMID: 30361418). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04086264 | Phase Ib/II | IMGN632 IMGN632 + Venetoclax Azacitidine + IMGN632 Azacitidine + IMGN632 + Venetoclax | IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia | Active, not recruiting | USA | ITA | GBR | FRA | ESP | DEU | 0 |
| NCT03386513 | Phase Ib/II | IMGN632 | Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN | Active, not recruiting | USA | ITA | GBR | FRA | ESP | DEU | 0 |
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