Therapy Detail

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Therapy Name	LAM-003
Synonyms
Therapy Description	LAM-003 is a prodrug that is metabolized by esterases into the active HSP90 inhibitor drug, LAM-003A, which potentially induces cytotoxicity, and inhibits viability and tumor growth (PMID: 31751472).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
LAM-003		LAM003\|LAM 003	HSP90 Inhibitor 35	LAM-003 is a prodrug that is metabolized by esterases into the active HSP90 inhibitor drug, LAM-003A, which potentially induces cytotoxicity, and inhibits viability and tumor growth (PMID: 31751472).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 D835X	acute myeloid leukemia	predicted - sensitive	LAM-003	Preclinical - Patient cell culture	Actionable	In a preclinical study, patient-derived acute myeloid leukemia cells harboring FLT3 D835X demonstrated sensitivity to LAM-003 treatment in culture (PMID: 31751472).	31751472
FLT3 D835Y	acute myeloid leukemia	predicted - sensitive	LAM-003	Preclinical - Patient cell culture	Actionable	In a preclinical study, patient-derived acute myeloid leukemia cells harboring FLT3 D835Y demonstrated sensitivity to LAM-003 treatment in culture (PMID: 31751472).	31751472
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	LAM-003	Preclinical - Patient cell culture	Actionable	In a preclinical study, LAM-003 treatment inhibited colony formation, and reduced viability of acute myeloid cell lines harboring FLT3 internal tandem duplication (ITD) in the presence of stromal factors that confer resistance to Xospata (gilteritinib) and Crenolanib, and induced apoptosis in patient-derived cells in culture, and induced tumor regression, and increased survival in cell line xenograft models (PMID: 31751472).	31751472
FLT3 exon 14 ins FLT3 D835Y	acute myeloid leukemia	sensitive	LAM-003	Preclinical - Patient cell culture	Actionable	In a preclinical study, LAM-003 treatment inhibited viability of an acute myeloid leukemia cell line and patient-derived cells harboring FLT3 internal tandem duplication (ITD) and FLT3 D835Y in culture (PMID: 31751472).	31751472
FLT3 exon 14 ins	Advanced Solid Tumor	sensitive	LAM-003	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing FLT3 internal tandem duplication (ITD) demonstrated sensitivity to LAM-003 treatment in culture (PMID: 31751472).	31751472
FLT3 exon 14 ins FLT3 F691L	Advanced Solid Tumor	sensitive	LAM-003	Preclinical - Cell culture	Actionable	In a preclinical study, transformed cells expressing FLT3 internal tandem duplication (ITD) and FLT3 F691L demonstrated sensitivity to LAM-003 treatment in culture (PMID: 31751472).	31751472

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT02546284	Phase I	LAM-003	Study of Lenzilumab in Previously Treated Patients With Chronic Myelomonocytic Leukemia (CMML)	Completed	USA	0
NCT03426605	Phase I	LAM-003	A Study of LAM-003 in Patients With Acute Myeloid Leukemia	Completed	USA	0

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