Therapy Detail
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| Therapy Name | Loncastuximab tesirine-lpyl |
| Synonyms | |
| Therapy Description |
Zynlonta (loncastuximab tesirine-lpyl) is a human anti-CD19 antibody in conjugation with a pyrrolobenzodiazepine (PBD) dimer toxin, which may specifically target CD19-positive tumor cells (Blood 2017 130(Suppl 1):187, PMID: 32012214). Zynlonta (loncastuximab tesirine-lpyl) is FDA approved for use in patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy (FDA.gov). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Loncastuximab tesirine-lpyl | Zynlonta | ADCT-402 | CD19 Antibody 21 | Zynlonta (loncastuximab tesirine-lpyl) is a human anti-CD19 antibody in conjugation with a pyrrolobenzodiazepine (PBD) dimer toxin, which may specifically target CD19-positive tumor cells (Blood 2017 130(Suppl 1):187, PMID: 32012214). Zynlonta (loncastuximab tesirine-lpyl) is FDA approved for use in patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05464719 | Phase II | Loncastuximab tesirine-lpyl | A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients With LBCL in PR After CAR T-cell Therapy | Recruiting | USA | 0 |
| NCT05453396 | Phase II | Loncastuximab tesirine-lpyl | Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies | Recruiting | USA | 0 |
| NCT05660395 | Phase I | Loncastuximab tesirine-lpyl | A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10) | Recruiting | USA | BRA | 2 |
| NCT04699461 | Phase II | Idelalisib Loncastuximab tesirine-lpyl | Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine Versus Idelalisib in Participants With Relapsed or Refractory Follicular Lymphoma (LOTIS 6) | Terminated | USA | POL | ITA | ISR | HUN | GBR | FRA | ESP | CHE | BEL | 0 |
| NCT05249959 | Phase II | Bendamustine + Cytarabine + Rituximab Loncastuximab tesirine-lpyl | Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in BTKi-treated (or Intolerant) Relapsed/Refractory Mantle Cell Lymphoma Patients. (FIL_COLUMN) | Recruiting | ITA | 0 |
| NCT03589469 | Phase II | Loncastuximab tesirine-lpyl | Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma | Completed | USA | ITA | GBR | CHE | 0 |
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