Therapy Detail
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| Therapy Name | JNJ-64457107 |
| Synonyms | |
| Therapy Description |
JNJ-64457107 (mitazalimab) is a CD40 agonist that may lead to a T-cell dependent antitumor response, potentially resulting in tumor growth inhibition (PMID: 25316820, PMID: 30664811). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| JNJ-64457107 | ADC-1013|Mitazalimab|JNJ 7107 | CD40 Antibody 16 | JNJ-64457107 (mitazalimab) is a CD40 agonist that may lead to a T-cell dependent antitumor response, potentially resulting in tumor growth inhibition (PMID: 25316820, PMID: 30664811). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02829099 | Phase I | JNJ-64457107 | A Study of Safety, Pharmacokinetics and Pharmacodynamics of JNJ-64457107 in Participants With Advanced Stage Tumors | Completed | ISR | ESP | 0 |
| NCT06205849 | Phase I | JNJ-64457107 | Intra-tumoral Mitazalimab (CD40 Antibody) With Irreversible Electroporation (IRE) in Locally Advanced Pancreas Cancer | Recruiting | USA | 0 |
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