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Therapy Name	Foretinib
Synonyms
Therapy Description	Foretinib (GSK1363089) is a multi-kinase inhibitor with activity against several receptor tyrosine kinases, including MET, KDR (VEGFR2), as well as ROS1 and NTRK fusions, which may result in decreased tumor angiogenesis and growth (PMID: 19808973, PMID: 26372962, PMID: 29463555, PMID: 30501104).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Foretinib		GSK1363089G\|XL880\|EXEL-2880	MET Inhibitor 59 ROS1 Inhibitor 23 TrkA Receptor Inhibitor 8 TYRO3 Inhibitor 7 VEGFR2 Inhibitor 37	Foretinib (GSK1363089) is a multi-kinase inhibitor with activity against several receptor tyrosine kinases, including MET, KDR (VEGFR2), as well as ROS1 and NTRK fusions, which may result in decreased tumor angiogenesis and growth (PMID: 19808973, PMID: 26372962, PMID: 29463555, PMID: 30501104).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	Foretinib	Preclinical - Pdx & cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cell lines and primary patient-derived acute myeloid leukemia cells harboring FLT3-ITD in culture, led to decreased tumor burden and improved survival in a cell line and a patient-derived xenograft (PDX) model (PMID: 38231480).	38231480
FLT3 exon 14 ins	hematologic cancer	sensitive	Foretinib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited growth of cultured cells expressing FLT3-ITD mutations, and led to decreased tumor burden and improved survival in a cell line xenograft model (PMID: 38231480).	38231480
FLT3 exon 14 ins FLT3 D835Y	hematologic cancer	sensitive	Foretinib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3-ITD with FLT3 D835Y, and led to improved survival in a cell line xenograft model (PMID: 38231480).	38231480
FLT3 exon 14 ins FLT3 F691L	hematologic cancer	sensitive	Foretinib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3-ITD with FLT3 F691L, and inhibited tumor cell growth in a cell line xenograft model (PMID: 38231480).	38231480
FLT3 exon 14 ins FLT3 Y842C	hematologic cancer	sensitive	Foretinib	Preclinical - Cell line xenograft	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3-ITD with FLT3 Y842C and improved survival in a cell line xenograft model (PMID: 38231480).	38231480
FLT3 D835E	acute myeloid leukemia	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of primary patient-derived acute myeloid leukemia blasts harboring FLT3 D835E in culture (PMID: 38231480).	38231480
FLT3 D835V	acute myeloid leukemia	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of primary patient-derived acute myeloid leukemia blasts harboring FLT3 D835V in culture (PMID: 38231480).	38231480
FLT3 D835V	hematologic cancer	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3 D835V (PMID: 38231480).	38231480
FLT3 D835Y	hematologic cancer	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3 D835Y (PMID: 38231480).	38231480
FLT3 exon 14 ins FLT3 D835V	acute myeloid leukemia	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of primary patient-derived acute myeloid leukemia blasts harboring FLT3-ITD with FLT3 D835V in culture (PMID: 38231480).	38231480
FLT3 exon 14 ins FLT3 D835V	hematologic cancer	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3-ITD with FLT3 D835V (PMID: 38231480).	38231480
FLT3 exon 14 ins FLT3 D835Y	acute myeloid leukemia	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of primary patient-derived acute myeloid leukemia blasts harboring FLT3-ITD with FLT3 D835Y in culture (PMID: 38231480).	38231480
FLT3 exon 14 ins NRAS G12C	acute myeloid leukemia	decreased response	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, acute myeloid leukemia cells harboring FLT3-ITD and expressing NRAS G12C were less sensitive to Foretinib (GSK1363089) in culture (PMID: 38231480).	38231480
FLT3 N676K	hematologic cancer	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3 N676K (PMID: 38231480).	38231480
FLT3 Y842C	hematologic cancer	sensitive	Foretinib	Preclinical - Cell culture	Actionable	In a preclinical study, Foretinib (GSK1363089) inhibited viability of cultured cells expressing FLT3 Y842C (PMID: 38231480).	38231480

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