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Drug Detail
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| Drug Name | Foretinib |
| Trade Name | |
| Synonyms | GSK1363089G|XL880|EXEL-2880 |
| Drug Descriptions |
Foretinib (GSK1363089) is a multi-kinase inhibitor with activity against several receptor tyrosine kinases, including MET, KDR (VEGFR2), as well as ROS1 and NTRK fusions, which may result in decreased tumor angiogenesis and growth (PMID: 19808973, PMID: 26372962, PMID: 29463555, PMID: 30501104). |
| DrugClasses | MET Inhibitor 59 ROS1 Inhibitor 22 TrkA Receptor Inhibitor 8 TYRO3 Inhibitor 7 VEGFR2 Inhibitor 37 |
| CAS Registry Number | 849217-64-7 |
| NCIT ID | C80058 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Foretinib | Foretinib | 15 | 0 |
| Foretinib + PLX4720 | Foretinib PLX4720 | 0 | 0 |
| Foretinib + Rucaparib | Foretinib Rucaparib | 0 | 0 |
| Foretinib + Veliparib | Foretinib Veliparib | 0 | 0 |
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