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Drug Name | M8891 |
Trade Name | |
Synonyms | CS-0109402 |
Drug Descriptions |
M8891 is an inhibitor of methionine aminopeptidase 2 (MetAP2), which results in cleavage of the aminoterminal methionine residue from an early forming protein, thereby disrupting protein synthesis and potentially result in reduced proliferation of endothelial cells (PMID: 31725285). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C142831 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Axitinib + M8891 | Axitinib M8891 | 1 | 0 |
Cabozantinib + M8891 | Cabozantinib M8891 | 1 | 0 |
M8891 | M8891 | 1 | 1 |
M8891 + Sunitinib | M8891 Sunitinib | 1 | 0 |