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Therapy Name	Galinpepimut-S + Pembrolizumab
Synonyms
Therapy Description	Galinpepimut-S is a WT1 vaccine comprised of four WT1 peptides, which may result in a CD4 and CD8 T cell immune response against WT1-expressing tumor cells (PMID: 28972039).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Galinpepimut-S		SLS-001\|SLS001\|SLS 001		Galinpepimut-S (SLS-001) is a WT1 vaccine comprised of four WT1 peptides, which may result in a CD4 and CD8 T cell immune response against WT1-expressing tumor cells (PMID: 28972039, PMID: 29386195).
Pembrolizumab	Keytruda	MK-3475	Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 129	Keytruda (pembrolizumab) is an antibody against PD-1 that activates T-cell mediated anti-tumor immune response (PMID: 25977344). Keytruda (pembrolizumab) is approved in melanoma, SCLC, HNSCC, classical Hodgkin Lymphoma, PMBL, urothelial carcinoma, HCC, Merkel cell carcinoma, NMIBC, cutaneous SCC, MSI-H or dMMR or TMB high advanced solid tumors, NSCLC and CD274 (PD-L1)-positive NSCLC, esophageal SCC, cervical cancer, and TNBC, in combination with platnum-based chemo in NSCLC, with pemetrexed and platinum in pleural mesothelioma and non-sNSCLC with no EGFR or ALK mutations, with carboplatin and paclitaxel/nab-paclitaxel in sNSCLC, with axitinib or lenvatinib in RCC, with lenvatinib in endometrial carcinoma that is not MSI-H or dMMR, in combination with platinum and fluoropyrimidine-based chemo for esophageal or gastroesophageal carcinoma, in combination with Herceptin (trastuzumab), fluoropyrimidine- and platinum-containing chemo for CD274 (PD-L1)-positive, HER2-positive gastric or GEJ adenocarcinoma, in combination with fluoropyrimidine- and platinum-containing chemo for HER2-negative gastric or GEJ adenocarcinoma, in combination with platinum-based chemotherapy, with or without bevacizumab, for patients with CD274 (PD-L1)-positive (CPS>=1) cervical cancer, in combination with gemcitabine and cisplatin for biliary tract cancer, in combination with chemoradiation for cervical cancer, and in combination with carboplatin and paclitaxel for endometrial carcinoma (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03761914	Phase Ib/II	Galinpepimut-S Galinpepimut-S + Pembrolizumab Pembrolizumab Sargramostim	Galinpepimut-S in Combination With Pembrolizumab in Patients With Selected Advanced Cancers	Completed	USA	0

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