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Therapy Name ACTR087 + Trastuzumab
Synonyms
Therapy Description

ACTR087 is a chimeric construct consisting of the extracellular domain of CD16 linked to CD3zeta signaling and 41BB co-stimulatory domains delivered into human T-cells via gamma-retrovirus, which may lead to enhanced anti-tumor activity in combination with tumor-targeting antibodies (Blood 2016, 128(22):3512).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ACTR087 ACTR-087|ACTR 087 ACTR087 is a chimeric construct consisting of the extracellular domain of CD16 linked to CD3zeta signaling and 41BB co-stimulatory domains delivered into human T-cells via gamma-retrovirus, which may lead to enhanced anti-tumor activity in combination with tumor-targeting antibodies (Blood 2016, 128(22):3512).
Trastuzumab Herceptin Anti HER2 HER2 (ERBB2) Antibody 76 Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03680560 Phase I ACTR707 + Trastuzumab ACTR087 + Trastuzumab Study of ACTR T Cell Product in Combination With Trastuzumab in Subjects With HER2-Positive Advanced Solid Tumor Cancers Terminated USA 0


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