Therapy Detail
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| Therapy Name | Dexamethasone + Melflufen |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Dexamethasone | Adexone | Desametasone | ||
| Melflufen | mel-flufen|Melphalan Flufenamide | Chemotherapy - Alkylating 18 | Melflufen (Melphalan Flufenamide) is a lipophilic alkylating agent that induces DNA damage, potentially resulting in increased tumor cell death (PMID: 27098276, PMID: 29029544). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02963493 | Phase II | Dexamethasone + Melflufen | A Study of Melflufen in Combination With Dexamethasone in Relapsed Refractory Multiple Myeloma Patients (HORIZON) | Completed | USA | ITA | FRA | ESP | 0 |
| NCT03151811 | Phase III | Dexamethasone + Pomalidomide Dexamethasone + Melflufen | A Study of Melflufen-dex or Pomalidomide-dex for RRMM Patients Refractory to Lenalidomide (OCEAN) | Terminated | USA | ROU | POL | NOR | NLD | LTU | ITA | ISR | HUN | GRC | GBR | FRA | EST | ESP | DNK | CZE | BEL | AUT | 3 |
| NCT04534322 | Expanded access | Dexamethasone + Melflufen | Expanded Access Program for Melphalan Flufenamide (Melflufen) in Triple Class Refractory Multiple Myeloma (sEAPort) | Approved for marketing | USA | 0 |
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