Therapy Detail
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| Therapy Name | Dexamethasone + Pomalidomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Dexamethasone | Adexone | Desametasone | ||
| Pomalidomide | Pomalyst | CC-4047 | Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02726581 | Phase III | Elotuzumab Nivolumab Dexamethasone + Pomalidomide | Study of Combinations of Nivolumab, Elotuzumab, Pomalidomide and Dexamethasone in Multiple Myeloma | Completed | USA | TUR | SWE | NOR | ITA | ISR | GRC | ESP | DNK | DEU | CZE | CHE | CAN | AUT | 2 |
| NCT05455320 | Phase III | Daratumumab + Dexamethasone + Pomalidomide + Talquetamab-tgvs Daratumumab + Dexamethasone + Talquetamab-tgvs Dexamethasone + Pomalidomide | A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma | Recruiting | USA | TUR | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CZE | BRA | BEL | 4 |
| NCT03539744 | Phase III | Dexamethasone + Pomalidomide Dexamethasone + Venetoclax | A Study of Venetoclax and Dexamethasone Compared With Pomalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (CANOVA) | Active, not recruiting | USA | TUR | SWE | ITA | ISR | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | AUS | 6 |
| NCT04162210 | Phase III | Dexamethasone + Pomalidomide belantamab mafodotin-blmf | Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) | Active, not recruiting | USA | POL | NLD | ITA | HUN | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BGR | BEL | AUS | 4 |
| NCT03151811 | Phase III | Dexamethasone + Pomalidomide Dexamethasone + Melflufen | A Study of Melflufen-dex or Pomalidomide-dex for RRMM Patients Refractory to Lenalidomide (OCEAN) | Terminated | USA | ROU | POL | NOR | NLD | LTU | ITA | ISR | HUN | GRC | GBR | FRA | EST | ESP | DNK | CZE | BEL | AUT | 3 |
| NCT02548962 | Phase Ib/II | Ibrutinib Dexamethasone + Pomalidomide | Study of Ibrutinib in Combination With Pomalidomide and Dexamethasone in Subjects With Relapsed/Refractory Multiple Myeloma | Terminated | USA | GRC | ESP | DEU | CZE | AUS | 0 |
| NCT02654132 | Phase II | Dexamethasone + Pomalidomide Elotuzumab | Trial of Elotuzumab With or Without Pomalidomide and Low-dose Dexamethasone to Treat Refractory and Relapsed and Refractory Multiple Myeloma | Completed | USA | POL | NLD | ITA | GRC | FRA | ESP | DEU | CAN | AUS | 1 |
| NCT02990338 | Phase III | Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Pomalidomide | Multinational Clinical Study Comparing Isatuximab, Pomalidomide, and Dexamethasone to Pomalidomide and Dexamethasone in Refractory or Relapsed and Refractory Multiple Myeloma Patients (ICARIA-MM) | Completed | USA | TUR | SWE | SVK | POL | NZL | NOR | ITA | HUN | GRC | GBR | FRA | ESP | DNK | DEU | CZE | CAN | BEL | AUS | 5 |
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