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Therapy Name	Acalabrutinib + Rituximab
Synonyms
Therapy Description	Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma (FDA.gov).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Acalabrutinib	Calquence	ACP-196	BTK inhibitor 38	Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma, and in combination with Treanda (bendamustine) and Rituxan (rituximab) in patients with untreated mantle cell lymphoma who are ineligible for autologous hematopoietic stem cell transplantation (FDA.gov).
Rituximab	Rituxan	IDEC-C2B8\|MabThera	CD20 Antibody 25	Rituxan (rituximab) is a chimeric mononclonal antibody that binds to CD20 on B-cells, resulting in induction of complement-dependent and antibody-dependent cytotoxicity, and potentially leading to decreased B-cell tumor growth (PMID: 28983798). Rituxan (rituximab) is FDA approved for use as monotherapy or in combination with chemotherapy in CD20-positive B-cell non-Hodgkin lymphoma, in combination with fludarabine and cyclophosphamide in CD20-positive chronic lymphocytic leukemia, and in combination with chemotherapy in pediatric patients (6 month to 18 years of age) with treatment-naive, CD20-positive diffuse large B-cell lymphoma, Burkitt lymphoma, Burkitt-like lymphoma, or mature B-cell acute leukemia (B-AL) (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT04765111	Phase II	Acalabrutinib + Rituximab	Acalabrutinib and Rituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma	Active, not recruiting	USA	0
NCT03788291	Phase II	Acalabrutinib + Rituximab	Acalabrutinib and High Frequency Low Dose Subcutaneous Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma	Completed	USA	0
NCT05004064	Phase II	Acalabrutinib + Rituximab	Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma (CARAMEL)	Recruiting	GBR	0
NCT05065554	Phase II	Acalabrutinib + Rituximab	ACALA-R In Anti-MAG Neuropathy Mediated Neuropathy	Recruiting	USA	0
NCT05495464	Phase I	Cyclophosphamide + Fludarabine Brexucabtagene autoleucel + Cyclophosphamide + Fludarabine Acalabrutinib + Rituximab	A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma	Recruiting	USA	0
NCT05952024	Phase II	Acalabrutinib + Rituximab	Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL (ACRUE)	Recruiting	USA \| BRA	2

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