Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Acalabrutinib
Trade Name Calquence
Synonyms ACP-196
Drug Descriptions

Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma (FDA.gov).

DrugClasses BTK inhibitor 37
CAS Registry Number 1420477-60-6
NCIT ID C113442

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib Acalabrutinib 3 35
Acalabrutinib + ACP-319 ACP-319 Acalabrutinib 0 0
Acalabrutinib + APR-246 APR-246 Acalabrutinib 0 1
Acalabrutinib + axicabtagene ciloleucel Acalabrutinib axicabtagene ciloleucel 0 1
Acalabrutinib + AZD0466 AZD0466 Acalabrutinib 0 0
Acalabrutinib + AZD4320 AZD4320 Acalabrutinib 0 0
Acalabrutinib + AZD4573 AZD4573 Acalabrutinib 0 1
Acalabrutinib + Bendamustine + Cytarabine + Rituximab Acalabrutinib Bendamustine Cytarabine Rituximab 0 2
Acalabrutinib + Bendamustine + Rituximab Acalabrutinib Bendamustine Rituximab 0 4
Acalabrutinib + Bortezomib + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab Acalabrutinib Bortezomib Cyclophosphamide Doxorubicin Prednisone Rituximab 0 1
Acalabrutinib + Bortezomib + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab Hyaluronidase Acalabrutinib Bortezomib Cyclophosphamide Doxorubicin Prednisone Rituximab Hyaluronidase 0 1
Acalabrutinib + Carboplatin + Etoposide + Ifosfamide + Rituximab Acalabrutinib Carboplatin Etoposide Ifosfamide Rituximab 0 2
Acalabrutinib + CD19R(EQ)28zetaEGFRt+ Tn/mem cells Acalabrutinib CD19R(EQ)28zetaEGFRt+ Tn/mem cells 0 1
Acalabrutinib + Ceralasertib Acalabrutinib Ceralasertib 0 1
Acalabrutinib + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Rituximab + Vincristine Sulfate Acalabrutinib Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Vincristine Sulfate 0 1
Acalabrutinib + Cyclophosphamide + Doxorubicin + Lenalidomide + Prednisone + Rituximab + Tafasitamab-cxix + Vincristine Sulfate Acalabrutinib Cyclophosphamide Doxorubicin Lenalidomide Prednisone Rituximab Tafasitamab-cxix Vincristine Sulfate 0 1
Acalabrutinib + Cyclophosphamide + Doxorubicin + Prednisolone + Rituximab + Vincristine Sulfate Acalabrutinib Cyclophosphamide Doxorubicin Prednisolone Rituximab Vincristine Sulfate 0 2
Acalabrutinib + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate Acalabrutinib Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine Sulfate 0 4
Acalabrutinib + Cytarabine + Rituximab Acalabrutinib Cytarabine Rituximab 0 1
Acalabrutinib + Cytarabine + Rituximab Hyaluronidase Acalabrutinib Cytarabine Rituximab Hyaluronidase 0 1
Acalabrutinib + Danvatirsen Acalabrutinib Danvatirsen 0 1
Acalabrutinib + Durvalumab Acalabrutinib Durvalumab 0 1
Acalabrutinib + Durvalumab + Venetoclax Acalabrutinib Durvalumab Venetoclax 0 1
Acalabrutinib + Duvelisib Acalabrutinib Duvelisib 0 1
Acalabrutinib + Glofitamab-gxbm + Obinutuzumab Acalabrutinib Glofitamab-gxbm Obinutuzumab 0 1
Acalabrutinib + KRT-232 Acalabrutinib KRT-232 0 1
Acalabrutinib + Lenalidomide + Rituximab Acalabrutinib Lenalidomide Rituximab 0 2
Acalabrutinib + Lenalidomide + Rituximab + Tafasitamab-cxix Acalabrutinib Lenalidomide Rituximab Tafasitamab-cxix 0 1
Acalabrutinib + Lisocabtagene maraleucel Acalabrutinib Lisocabtagene maraleucel 0 1
Acalabrutinib + Loncastuximab tesirine-lpyl Acalabrutinib Loncastuximab tesirine-lpyl 0 1
Acalabrutinib + Obinutuzumab Acalabrutinib Obinutuzumab 2 6
Acalabrutinib + Obinutuzumab + Tafasitamab-cxix Acalabrutinib Obinutuzumab Tafasitamab-cxix 0 1
Acalabrutinib + Obinutuzumab + Venetoclax Acalabrutinib Obinutuzumab Venetoclax 0 5
Acalabrutinib + Pacritinib Acalabrutinib Pacritinib 0 1
Acalabrutinib + Pembrolizumab Acalabrutinib Pembrolizumab 0 0
Acalabrutinib + Rituximab Acalabrutinib Rituximab 0 5
Acalabrutinib + Rituximab + Venetoclax Acalabrutinib Rituximab Venetoclax 0 1
Acalabrutinib + Rituximab Hyaluronidase Acalabrutinib Rituximab Hyaluronidase 0 0
Acalabrutinib + Tafasitamab-cxix Acalabrutinib Tafasitamab-cxix 0 1
Acalabrutinib + Tazemetostat Acalabrutinib Tazemetostat 0 2
Acalabrutinib + Ublituximab + Umbralisib Acalabrutinib Ublituximab Umbralisib 0 2
Acalabrutinib + Venetoclax Acalabrutinib Venetoclax 0 9
Acalabrutinib + Vistusertib Acalabrutinib Vistusertib 0 1


Additional content available in CKB BOOST