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| Drug Name | Acalabrutinib |
| Trade Name | Calquence |
| Synonyms | ACP-196 |
| Drug Descriptions |
Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma, and in combination with Treanda (bendamustine) and Rituxan (rituximab) in patients with untreated mantle cell lymphoma who are ineligible for autologous hematopoietic stem cell transplantation (FDA.gov). |
| DrugClasses | BTK inhibitor 38 |
| CAS Registry Number | 1420477-60-6 |
| NCIT ID | C113442 |
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