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Therapy Name MK-0482
Synonyms
Therapy Description

MK-0482 binds to ILT3 and prevents binding of ILT-3 ligands, leading to inhibition of ILT-3 dependent signaling, which may lead to increased antitumor immune response (J Clin Oncol 42, 2024 (suppl 16; abstr 2046), NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MK-0482 MK 0482|MK0482 MK-0482 binds to ILT3 and prevents binding of ILT-3 ligands, leading to inhibition of ILT-3 dependent signaling, which may lead to increased antitumor immune response (J Clin Oncol 42, 2024 (suppl 16; abstr 2046), NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05038800 Phase I MK-0482 A Study to Evaluate MK-0482 for Relapsed/Refractory Acute Myeloid Leukemia (AML) (MK-0482-002) Terminated USA | ISR | ESP 0
NCT03918278 Phase I MK-0482 MK-0482 + Pembrolizumab A Study of MK-0482 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-0482-001) Active, not recruiting USA | ITA | ISR | ESP | CAN | AUS 2


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