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Therapy Name Talquetamab-tgvs
Synonyms
Therapy Description

Talvey (talquetamab-tgvs) is a bispecific antibody that targets CD3 and GPRC5D, potentially resulting in increased immune response against GPRC5D-expressing tumor cells (PMID: 32040549). Talvey (talquetamab-tgvs) is FDA-approved for use in adult patients with relapsed or refractory multiple myeloma who have received four or more prior lines of therapy (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Talquetamab-tgvs Talvey JNJ64407564|JNJ 64407564|JNJ-64407564 CD3 Antibody 99 Talvey (talquetamab-tgvs) is a bispecific antibody that targets CD3 and GPRC5D, potentially resulting in increased immune response against GPRC5D-expressing tumor cells (PMID: 32040549). Talvey (talquetamab-tgvs) is FDA-approved for use in adult patients with relapsed or refractory multiple myeloma who have received four or more prior lines of therapy (FDA.gov).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06505369 Phase II Talquetamab-tgvs Teclistamab Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Bispecific T-cell Redirectors as Part of First Line Treatment in Transplant Eligible Multiple Myeloma Patients (TALTEC) Recruiting NOR | EST | DNK 0
NCT05461209 Phase III belantamab mafodotin-blmf Talquetamab-tgvs A Study of Comparing Talquetamab to Belantamab Mafodotin in Participants With Relapsed/Refractory Multiple Myeloma (MonumenTAL-5) Withdrawn USA | POL 0
NCT06461988 Phase II Lenalidomide + Talquetamab-tgvs Talquetamab-tgvs Talquetamab & Lenalidomide as Post Stem Cell Transplant Maintenance in Multiple Myeloma Not yet recruiting USA 0
NCT05503550 Expanded access Talquetamab-tgvs Pre-Approval Access Single Patient Request for Talquetamab in Relapsed or Refractory Multiple Myeloma No longer available SVN | ISL | BEL 1
NCT06572605 Phase Ib/II Talquetamab-tgvs External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease Not yet recruiting USA 0
NCT03399799 Phase I Talquetamab-tgvs Dose Escalation Study of JNJ-64407564 in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | NLD | ESP | BEL 0
NCT04634552 Phase II Talquetamab-tgvs A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | POL | NLD | ISR | FRA | ESP | DEU | BEL 3
NCT06066346 Phase II Talquetamab-tgvs A Study of Talquetamab for People With Multiple Myeloma Who Have Received BCMA CAR T-Cell Therapy Recruiting USA 0


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