Therapy Detail
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| Therapy Name | AB680 + Zimberelimab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AB680 | AB-680|AB 680|quemliclustat | Adenosine Targeting 23 CD73 Antibody 12 | AB680 is an inhibitor that selectively targets CD73, resulting in decreased production of extracellular adenosine (ADO), and potentially leading to decreased ADO-mediated T-cell suppression and improved anti-tumor immunity (Cancer Res 2018;78(13 Suppl):Abstract nr 1756, PMID: 32614585). | |
| Zimberelimab | GLS-010|AB122|AB-122|GLS010 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 | Zimberelimab (GLS-010) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28679395). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04104672 | Phase I | AB680 + Zimberelimab | A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies | Recruiting | USA | 0 |
| NCT06048484 | Phase II | Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Pegfilgrastim AB680 + Etrumadenant + Zimberelimab AB680 + Zimberelimab Zimberelimab | Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma (AIRPanc) | Recruiting | USA | 0 |
| NCT05676931 | Phase II | AB680 + Zimberelimab AB154 + Zimberelimab AB154 + AB680 + Zimberelimab AB680 + Docetaxel + Zimberelimab AB154 + Docetaxel + Zimberelimab | Study With Immunotherapy Combinations in Participants With Metastatic Non-Small Cell Lung Cancer (EDGE-Lung) | Recruiting | USA | POL | ITA | GBR | FRA | ESP | AUS | 3 |
| NCT05329766 | Phase II | AB680 + Zimberelimab AB154 + Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab AB154 + Zimberelimab Fluorouracil + Leucovorin + Oxaliplatin + Zimberelimab | A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies (EDGE-Gastric) | Recruiting | USA | FRA | CAN | 3 |
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