Therapy Detail
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| Therapy Name | Azenosertib |
| Synonyms | |
| Therapy Description |
Azenosertib inhibits WEE1, which potentially increases DNA damage leading to induction of apoptosis, decreased tumor cell proliferation, and inhibition of tumor growth (PMID: 40231599, PMID: 39755818). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Azenosertib | ZNc3|ZN c3|ZN-c3 | WEE1 Inhibitor 8 | Azenosertib inhibits WEE1, which potentially increases DNA damage leading to induction of apoptosis, decreased tumor cell proliferation, and inhibition of tumor growth (PMID: 40231599, PMID: 39755818). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05368506 | Phase I | Azenosertib | ZN-c3 for the Treatment of Metastatic Triple-Negative Breast Cancer and Advanced Ovarian Cancer | Withdrawn | 0 | |
| NCT06369155 | Phase II | Azenosertib | Azenosertib in Uterine Serous Carcinoma: Biomarker Study | Recruiting | USA | 0 |
| NCT04158336 | Phase Ib/II | Azenosertib Azenosertib + Talazoparib Azenosertib + Pembrolizumab | A Study of ZN-c3 in Participants With Solid Tumors | Unknown status | USA | 0 |
| NCT04814108 | Phase II | Azenosertib | A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma | Recruiting | USA | CAN | AUS | 1 |
| NCT05128825 | Phase II | Azenosertib | A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer (DENALI) | Recruiting | USA | POL | ITA | FRA | ESP | BEL | AUS | 0 |
| NCT05682170 | Phase Ib/II | Azenosertib + ZN-d5 Azenosertib | Study of the ZN-d5 and ZN-c3 in Subjects With Acute Myeloid Leukemia (AML) | Terminated | USA | 0 |
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