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Therapy Name ATLCAR.CD30 cells + ATLCAR.CD30.CCR4 cells
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ATLCAR.CD30 cells CAR.CD30-expressing autologous T lymphocytes ATLCAR.CD30 cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets TNFRSF8 (CD30), which may induce lysis of TNFRSF8 (CD30)-positive tumor cells (PMID: 32701411, NCI Drug Dictionary).
ATLCAR.CD30.CCR4 cells ATLCAR.CD30-CD28zeta-CCR4 cells ATLCAR.CD30.CCR4 cells are autologous T-lymphocytes engineered to express CCR4 linked to a chimeric antigen receptor (CAR) targeting CD30 and the CD28 and CD3zeta co-stimulatory domains, which potentially increase antitumor immune response (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03602157 Phase I ATLCAR.CD30.CCR4 cells Bendamustine + Fludarabine ATLCAR.CD30 cells + ATLCAR.CD30.CCR4 cells Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL Recruiting USA 0


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