Therapy Detail
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| Therapy Name | ATLCAR.CD30 cells + ATLCAR.CD30.CCR4 cells |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ATLCAR.CD30 cells | CAR.CD30-expressing autologous T lymphocytes | CD30 (TNFRSF8) Immune Cell Therapy 5 | ATLCAR.CD30 cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets TNFRSF8 (CD30), which may induce lysis of TNFRSF8 (CD30)-positive tumor cells (PMID: 32701411, NCI Drug Dictionary). | |
| ATLCAR.CD30.CCR4 cells | ATLCAR.CD30-CD28zeta-CCR4 cells | CD30 (TNFRSF8) Immune Cell Therapy 5 | ATLCAR.CD30.CCR4 cells are autologous T-lymphocytes engineered to express CCR4 linked to a chimeric antigen receptor (CAR) targeting CD30 and the CD28 and CD3zeta co-stimulatory domains, which potentially increase antitumor immune response (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03602157 | Phase I | ATLCAR.CD30.CCR4 cells Bendamustine + Fludarabine ATLCAR.CD30 cells + ATLCAR.CD30.CCR4 cells | Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL | Recruiting | USA | 0 |
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