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Therapy Name MEDI2228
Synonyms
Therapy Description

MEDI2228 is an antibody-drug conjugate comprising a BCMA targeted antibody linked to a pyrrolobenzodiazepine dimer, which delivers the DNA cross-linking agent to BCMA-expressing tumor cells, potentially resulting in decreased tumor growth (Blood (2017) 130 (Supplement 1): 3153, PMID: 32060401).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MEDI2228 MEDI-2228|anti-BCMA ADC MEDI2228|Anti-BCMA/PBD MEDI2228 TNFRSF17 Antibody 20 MEDI2228 is an antibody-drug conjugate comprising a BCMA targeted antibody linked to a pyrrolobenzodiazepine dimer, which delivers the DNA cross-linking agent to BCMA-expressing tumor cells, potentially resulting in decreased tumor growth (Blood (2017) 130 (Supplement 1): 3153, PMID: 32060401).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03489525 Phase I MEDI2228 MEDI2228 in Subjects With Relapsed/Refractory Multiple Myeloma (MEDI2228) Completed USA | GRC | ESP | AUS 0


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