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Therapy Name | Subasumstat |
Synonyms | |
Therapy Description |
Subasumstat (TAK-981) is a small molecule inhibitor of the SUMO-activating enzyme (SAE), which may lead to activation of anti-tumor immune response and inhibition of tumor growth (PMID: 37420267). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Subasumstat | TAK981|TAK 981|TAK-981 | Subasumstat (TAK-981) is a small molecule inhibitor of the SUMO-activating enzyme (SAE), which may lead to activation of anti-tumor immune response and inhibition of tumor growth (PMID: 37420267). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT03648372 | Phase I | Subasumstat | A Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of TAK-981 in Adult Participants With Metastatic Solid Tumors or Lymphomas | Terminated | USA | 0 |
NCT04065555 | Phase I | Avelumab + Subasumstat Cetuximab Cetuximab + Subasumstat Subasumstat Avelumab | Intratumoral Microdosing of TAK-981 in Head and Neck Cancer | Completed | USA | 0 |