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Therapy Detail
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| Therapy Name | KAZ954 + Spartalizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| KAZ954 | KAZ-954|KAZ 954 | KAZ954 is a monoclonal antibody targeting ectonucleoside triphosphate diphosphohydrolase (ENTPD2), which inhibits the hydrolysis of ATP to ADP and potentially induces antibody-dependent cell-mediated cytotoxicity (ADCC) and inhibition of tumor growth (Mol Cancer Ther (2023) 22 (12_Supplement): PR015). | ||
| Spartalizumab | PDR001|PDR-001 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124 | Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32364844, PMID: 32179633). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04237649 | Phase I | KAZ954 + Spartalizumab KAZ954 + Taminadenant KAZ954 KAZ954 + NZV930 | KAZ954 Alone and With PDR001, NZV930 and NIR178 in Advanced Solid Tumors | Terminated | USA | ITA | ESP | CAN | 4 |
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