Therapy Detail
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| Therapy Name | Paclitaxel + Tomivosertib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
| Tomivosertib | eFT508|EFT-508 | MNK1/2 Inhibitor 3 | Tomivosertib (eFT508) inhibits MNK1/2 and phosphorylation of eIF4E, which may lead to impaired translation of CD274 (PD-L1), potentially resulting in decreased tumor cell proliferation and inhibition of tumor growth (PMID: 30643286, PMID: 34012509). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04261218 | Phase I | Paclitaxel + Tomivosertib | Safety, Pharmacodynamics, Pharmacokinetics, and Efficacy of Tomivosertib Combined With Paclitaxel in Advanced Breast Cancer | Completed | CAN | 0 |
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