Tomivosertib
Drug Detail

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Drug Name Tomivosertib
Trade Name
Synonyms eFT508|EFT-508
Drug Descriptions

Tomivosertib (eFT508) inhibits MNK1/2 and phosphorylation of eIF4E, which may lead to impaired translation of CD274 (PD-L1), potentially resulting in decreased tumor cell proliferation and inhibition of tumor growth (PMID: 30643286, PMID: 34012509).
DrugClasses MNK1/2 Inhibitor 3
CAS Registry Number 1849590-01-7
NCIT ID C125062

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Tomivosertib Avelumab Tomivosertib 0 1
Azacitidine + Tomivosertib + Venetoclax Azacitidine Tomivosertib Venetoclax 0 1
Paclitaxel + Tomivosertib Paclitaxel Tomivosertib 0 1
Pembrolizumab + Pemetrexed Disodium + Tomivosertib Pembrolizumab Pemetrexed Disodium Tomivosertib 0 1
Pembrolizumab + Tomivosertib Pembrolizumab Tomivosertib 0 1
Tomivosertib Tomivosertib 0 6


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