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Therapy Name	TAK-733
Synonyms
Therapy Description	TAK-733 inhibits MEK1 and MEK2, preventing the activation of the RAS/RAF/MEK/ERK pathway, possibly inhibiting growth factor-mediated cell signaling and tumor cell proliferation (PMID: 26439693, PMID: 30396931).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
TAK-733		TAK733\|REC-4881\|REC4881\|REC 4881	MEK inhibitor (Pan) 27 MEK1 Inhibitor 27 MEK2 Inhibitor 25	TAK-733 inhibits MEK1 and MEK2, preventing the activation of the RAS/RAF/MEK/ERK pathway, possibly inhibiting growth factor-mediated cell signaling and tumor cell proliferation (PMID: 26439693, PMID: 30396931).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF L597S	melanoma	predicted - sensitive	TAK-733	Case Reports/Case Series	Actionable	In a Phase I trial, TAK-733 treatment resulted in a partial response after 2 cycles in a patient with metastatic melanoma harboring BRAF L597S, who remained progression-free for over 24 weeks (PMID: 22798288).	22798288
BRAF mut PIK3CA wild-type	colorectal cancer	predicted - sensitive	TAK-733	Preclinical - Pdx & cell culture	Actionable	In a preclinical study, mutations in BRAF, KRAS, or NRAS were associated with sensitivity to TAK-733 in colorectal cancer cell lines in culture, and patient-derived xenograft models harboring KRAS or BRAF mutations with wild-type PIK3CA demonstrated a trend toward higher tumor growth inhibition following TAK-733 treatment (PMID: 26439693).	26439693
NRAS mut PIK3CA wild-type	colorectal cancer	predicted - sensitive	TAK-733	Preclinical - Cell culture	Actionable	In a preclinical study, colorectal cancer cell lines harboring mutations in KRAS or NRAS and with wild-type PIK3CA demonstrated a trend toward increased sensitivity to TAK-733 in culture (PMID: 26439693).	26439693

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT06005974	Phase II	TAK-733	A Study of REC-4881 in Participants With Cancers Which Have an AXIN1 or APC Mutation	Active, not recruiting	USA	0

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