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Therapy Name ZW49
Synonyms
Therapy Description

ZW49 is an antibody-drug conjugate (ADC) comprising a bispecific ERBB2 (HER2) antibody linked to auristatin, which delivers the cytotoxic agent to ERBB2 (HER2)-expressing cells, potentially resulting in cell growth inhibition and tumor regression (Cancer Res 2019;79(4 Suppl):Abstract nr P6-17-13).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ZW49 ZW-49|ADC ZW49 HER2 (ERBB2) Antibody 76 HER2 (ERBB2) Antibody-Drug Conjugate 31 ZW49 is an antibody-drug conjugate (ADC) comprising a bispecific ERBB2 (HER2) antibody linked to auristatin, which delivers the cytotoxic agent to ERBB2 (HER2)-expressing cells, potentially resulting in cell growth inhibition and tumor regression (Cancer Res 2019;79(4 Suppl):Abstract nr P6-17-13).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03821233 Phase I ZW49 A Dose Finding Study of ZW49 in Patients With HER2-Positive Cancers Active, not recruiting USA | CAN | AUS 1


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