Therapy Detail

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Therapy Name belantamab mafodotin-blmf + Bortezomib + Dexamethasone + Lenalidomide
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Bortezomib Velcade Velcade (bortezomib) is a reversible proteasome inhibitor that inhibits survival of malignant cells and regulates bone remodeling (PMID: 26579531). Velcade (bortezomib) is FDA approved for the treatment of mantle cell lymphoma and multiple myeloma (FDA.gov).
Dexamethasone Adexone Desametasone
Lenalidomide Revlimid IMiD-1 Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov).
belantamab mafodotin-blmf Blenrep anti-BCMA ADC GSK2857916|J6M0-mcMMAF|GSK2857916 TNFRSF17 Antibody 20 Blenrep (belantamab mafodotin-blmf) is an antibody-drug conjugate comprising an antibody targeting BCMA linked to monomethyl auristatin F, which delivers the anti-microtubule agent to BCMA-expressing tumor cells, potentially resulting in increased tumor cell death and decreased tumor growth (PMID: 30442502, PMID: 24569262). Blenrep (belantamab mafodotin-blmf) is FDA approved for use in patients with relapse or refractory multiple myeloma who have received 4 or more prior therapies (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04091126 Phase III Bortezomib + Dexamethasone + Lenalidomide belantamab mafodotin-blmf + Bortezomib + Dexamethasone + Lenalidomide Bortezomib, Lenalidomide and Dexamethasone (VRd) With Belantamab Mafodotin Versus VRd Alone in Transplant Ineligible Multiple Myeloma Recruiting USA | POL | ITA | GBR | FRA | ESP | DEU | CAN | AUS 1
NCT04802356 Phase II belantamab mafodotin-blmf + Bortezomib + Dexamethasone + Lenalidomide Belantamab Mafodotin in Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Recruiting ESP 0


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