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Therapy Name AMXT1501 + Eflornithine
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AMXT1501 AMXT-1501 AMXT1501 inhibits polyamine transport, which may deplete intracellular polyamine pools and enhance growth inhibition by DFMO (PMID: 23457004).
Eflornithine Iwilfin DFMO|alpha-difluoromethylornithine Iwilfin (eflornithine) is an ornithine decarboxylase inhibitor that blocks polyamine production, resulting in reduced tumor cell proliferation (PMID: 32256343). Iwilfin (eflornithine) is FDA-approved for use in adult and pediatric patients with high-risk neuroblastoma who have responded to prior therapies (FDA.gov)

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03536728 Phase I AMXT1501 + Eflornithine Oral AMXT 1501 Dicaprate in Combination With DFMO Completed USA 0
NCT05500508 Phase Ib/II AMXT1501 + Eflornithine Oral AMXT 1501 Dicaprate in Combination With IV DFMO Terminated USA | AUS 0


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