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| Drug Name | Eflornithine |
| Trade Name | Iwilfin |
| Synonyms | DFMO|alpha-difluoromethylornithine |
| Drug Descriptions |
Iwilfin (eflornithine) is an ornithine decarboxylase inhibitor that blocks polyamine production, resulting in reduced tumor cell proliferation (PMID: 32256343). Iwilfin (eflornithine) is FDA-approved for use in adult and pediatric patients with high-risk neuroblastoma who have responded to prior therapies (FDA.gov) |
| DrugClasses | |
| CAS Registry Number | 70052-12-9 |
| NCIT ID | C226 |
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AMXT1501 + Eflornithine | AMXT1501 Eflornithine | 0 | 2 |
| Dinutuximab + Eflornithine + Irinotecan + Sargramostim + Temozolomide | Dinutuximab Eflornithine Irinotecan Sargramostim Temozolomide | 0 | 1 |
| Eflornithine | Eflornithine | 0 | 4 |
| Eflornithine + Etoposide | Eflornithine Etoposide | 0 | 1 |
| Eflornithine + Pembrolizumab | Eflornithine Pembrolizumab | 0 | 1 |
| Eflornithine + SAM486 | Eflornithine SAM486 | 0 | 0 |
| Eflornithine + Testosterone cypionate | Eflornithine Testosterone cypionate | 0 | 1 |