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Drug Name | Eflornithine |
Trade Name | Iwilfin |
Synonyms | DFMO|alpha-difluoromethylornithine |
Drug Descriptions |
Iwilfin (eflornithine) is an ornithine decarboxylase inhibitor that blocks polyamine production, resulting in reduced tumor cell proliferation (PMID: 32256343). Iwilfin (eflornithine) is FDA-approved for use in adult and pediatric patients with high-risk neuroblastoma who have responded to prior therapies (FDA.gov) |
DrugClasses | |
CAS Registry Number | 70052-12-9 |
NCIT ID | C226 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AMXT1501 + Eflornithine | AMXT1501 Eflornithine | 0 | 2 |
Dinutuximab + Eflornithine + Irinotecan + Sargramostim + Temozolomide | Dinutuximab Eflornithine Irinotecan Sargramostim Temozolomide | 0 | 1 |
Eflornithine | Eflornithine | 0 | 4 |
Eflornithine + Etoposide | Eflornithine Etoposide | 0 | 1 |
Eflornithine + Pembrolizumab | Eflornithine Pembrolizumab | 0 | 1 |
Eflornithine + SAM486 | Eflornithine SAM486 | 0 | 0 |
Eflornithine + Testosterone cypionate | Eflornithine Testosterone cypionate | 0 | 1 |