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Therapy Name | Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells |
Synonyms | |
Therapy Description |
Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells comprise CD4- and CD8-positive autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing an anti-CD19 fragment linked to the CD28 and CD3zeta signaling domains and a truncated human epidermal growth factor receptor (EGFRt), which potentially induce cytotoxicity against CD19-expressing tumor cells and antitumor activity (PMID: 28408462, NCI Drug Dictionary). |