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Drug Name Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells
Trade Name
Synonyms Autologous CD19 CAR+ EGFRt + CD4+ and CD8+ T cells
Drug Descriptions

Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells comprise CD4- and CD8-positive autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing an anti-CD19 fragment linked to the CD28 and CD3zeta signaling domains and a truncated human epidermal growth factor receptor (EGFRt), which potentially induce cytotoxicity against CD19-expressing tumor cells and antitumor activity (PMID: 28408462, NCI Drug Dictionary).

DrugClasses CD19 Immune Cell Therapy 62
CAS Registry Number NA
NCIT ID C137866

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells 0 3
Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells + Iomab-B Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells Iomab-B 0 1


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