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Therapy Name Anti-CD33 CAR-T cells
Synonyms
Therapy Description

Anti-CD33 CAR-T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD33 linked to TNFRSF9 (4-1BB) and CD3zeta signaling domains, which potentially induce lysis of CD33-expressing tumor cells and inhibit tumor growth (PMID: 25721896).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Anti-CD33 CAR-T cells CD33CART|CART-33 TCR zeta:CD137 Cells|Anti-CD33 CART cells Anti-CD33 CAR-T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD33 linked to TNFRSF9 (4-1BB) and CD3zeta signaling domains, which potentially induce lysis of CD33-expressing tumor cells and inhibit tumor growth (PMID: 25721896).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05672147 Phase I Anti-CD33 CAR-T cells CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia Recruiting USA 0
NCT03971799 Phase Ib/II Cyclophosphamide + Fludarabine Anti-CD33 CAR-T cells Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults With Relapsed/Refractory Acute Myeloid Leukemia Recruiting USA 0
NCT05984199 Phase Ib/II Anti-CD33 CAR-T cells Donor-Derived Anti-CD33 CAR T Cell Therapy (VCAR33) in Patients With Relapsed or Refractory AML After Allogeneic Hematopoietic Cell Transplant Recruiting USA 0
NCT05945849 Phase I Anti-CD33 CAR-T cells CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML Recruiting USA 0


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