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Therapy Name | VAX014 |
Synonyms | |
Therapy Description |
VAX014 is bacterial minicell therapeutic comprising E. coli engineered to express Invasin and the bacterial toxin perfringolysin O (PFO), which delivers the toxin to tumor cells expressing Integrin alpha3beta1 or alpha5beta1, potentially resulting in increased tumor cell apoptosis and decreased tumor growth (PMID: 27919942, PMID: 27119118). |