Therapy Detail
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| Therapy Name | GEN1042 |
| Synonyms | |
| Therapy Description |
GEN1042 is a bispecifc agonistic antibody that binds to CD40 and TNFRSF9 (CD137; 4-1BB), potentially resulting in increased T cell proliferation and anti-tumor immune response (PMID: 30400822). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GEN1042 | BNT 312|BNT-312|BNT312|GEN-1042|GEN 1042 | CD40 Antibody 16 TNFRSF9 Antibody 36 | GEN1042 is a bispecifc agonistic antibody that binds to CD40 and TNFRSF9 (CD137; 4-1BB), potentially resulting in increased T cell proliferation and anti-tumor immune response (PMID: 30400822). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05491317 | Phase Ib/II | GEN1042 GEN1042 + Pembrolizumab | A Safety and Antitumor Activity Trial of Immunoradiotherapy Combinations as a Treatment Option for Subjects With Metastatic Solid Tumors | Terminated | FRA | 0 |
| NCT04083599 | Phase Ib/II | GEN1042 | GEN1042 Safety Trial in Subjects With Malignant Solid Tumors | Active, not recruiting | USA | ITA | ISR | GBR | FRA | ESP | DNK | DEU | 4 |
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