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Therapy Name GEN1042
Synonyms
Therapy Description

GEN1042 is a bispecifc agonistic antibody that binds to CD40 and TNFRSF9 (CD137; 4-1BB), potentially resulting in increased T cell proliferation and anti-tumor immune response (PMID: 30400822).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GEN1042 BNT 312|BNT-312|BNT312|GEN-1042|GEN 1042 CD40 Antibody 14 TNFRSF9 Antibody 32 GEN1042 is a bispecifc agonistic antibody that binds to CD40 and TNFRSF9 (CD137; 4-1BB), potentially resulting in increased T cell proliferation and anti-tumor immune response (PMID: 30400822).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05491317 Phase Ib/II GEN1042 GEN1042 + Pembrolizumab A Safety and Antitumor Activity Trial of Immunoradiotherapy Combinations as a Treatment Option for Subjects With Metastatic Solid Tumors Recruiting FRA 0
NCT04083599 Phase Ib/II GEN1042 GEN1042 Safety Trial in Subjects With Malignant Solid Tumors Recruiting USA | ITA | ISR | GBR | FRA | ESP | DNK | DEU 4


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