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Therapy Name | CD5 CAR-T cells |
Synonyms | |
Therapy Description |
CD5 CAR-T cells are autologous T-cells engineered to express a chimeric antigen receptor (CAR) targeting CD5 fused to the intracellular signaling domain of CD28 and the T-cell receptor (TCR) zeta chain, which potentially induce toxicity against CD5-expressing tumor cells and inhibit tumor growth (PMID: 26056165). |