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Therapy Name CD5 CAR-T cells
Synonyms
Therapy Description

CD5 CAR-T cells are autologous T-cells engineered to express a chimeric antigen receptor (CAR) targeting CD5 fused to the intracellular signaling domain of CD28 and the T-cell receptor (TCR) zeta chain, which potentially induce toxicity against CD5-expressing tumor cells and inhibit tumor growth (PMID: 26056165).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CD5 CAR-T cells autologous CD5.CAR/28zeta CAR T cells|Anti-CD5 CAR T cells CD5 CAR-T cells are autologous T-cells engineered to express a chimeric antigen receptor (CAR) targeting CD5 fused to the intracellular signaling domain of CD28 and the T-cell receptor (TCR) zeta chain, which potentially induce toxicity against CD5-expressing tumor cells and inhibit tumor growth (PMID: 26056165).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03081910 Phase I CD5 CAR-T cells Cyclophosphamide + Fludarabine Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen (MAGENTA) Recruiting USA 0


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