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ID | DOID:60108 |
Name | brain glioma |
Definition | A brain cancer that has_material_basis_in glial cells. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer brain glioma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
PTEN loss | Gedatolisib | brain glioma | sensitive | detail... |
IDH1 act mut | LY3410738 | brain glioma | predicted - sensitive | detail... |
IDH2 act mut | LY3410738 | brain glioma | predicted - sensitive | detail... |
IDH1 R132X | Olutasidenib | brain glioma | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT00660621 | Phase II | Bevacizumab + Temozolomide | A Phase II Study Of Gliadel, Concomitant Temozolomide And Radiation, Followed By Dose Dense Therapy With Temozolomide Plus Bevacizumab For Newly Diagnosed Malignant High Grade Glioma | Unknown status | USA | 0 |
NCT00823459 | Phase II | Everolimus | Phase II Trial of RAD001 in Patients With Recurrent Low Grade Glioma | Completed | USA | 0 |
NCT01390948 | Phase II | Temozolomide Bevacizumab | A Study of Avastin (Bevacizumab) in Combination With Temolozomide (TMZ) and Radiotherapy in Paediatric and Adolescent Patients With High-Grade Glioma | Completed | SWE | POL | NLD | ITA | HUN | GBR | FRA | ESP | DNK | CZE | CAN | BEL | AUT | AUS | 0 |
NCT01580969 | Phase Ib/II | Bevacizumab | Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma | Completed | USA | 0 |
NCT01661400 | Phase I | Cyclophosphamide Thalidomide | Anti-Angiogenic Therapy Post Transplant (ASCR) for Relapsed and Refractory Pediatric Solid Tumors | Completed | USA | 0 |
NCT01672463 | Phase I | OKN-007 | Clinical Trial of IV OKN-007 in a Pilot Cohort of Human Recurrent Malignant Glioma Patients | Active, not recruiting | USA | 0 |
NCT01774253 | Phase II | Vismodegib | Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma | Terminated | USA | 0 |
NCT01967810 | Phase II | Bevacizumab Paclitaxel Trevatide | ANG1005 in Patients With Recurrent High-Grade Glioma | Completed | USA | 0 |
NCT02124772 | Phase I | Trametinib Dabrafenib + Trametinib | Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations | Completed | USA | GBR | FRA | CAN | AUS | 0 |
NCT02372006 | Phase Ib/II | Afatinib | Trial of Afatinib in Pediatric Tumours | Completed | USA | NLD | ITA | GBR | FRA | ESP | DNK | DEU | CAN | AUT | AUS | 1 |
NCT03122197 | Phase I | Letrozole | Study of Letrozole in Recurrent Gliomas | Recruiting | USA | 0 |
NCT03363217 | Phase Ib/II | Trametinib | Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway. | Active, not recruiting | CAN | 0 |
NCT03429803 | Phase I | Tovorafenib | DAY101 In Gliomas and Other Tumors | Active, not recruiting | USA | 0 |
NCT03576612 | Phase I | AdV-tk Temozolomide Valacyclovir Nivolumab | GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas (GMCI) | Active, not recruiting | USA | 0 |
NCT03796273 | Phase I | Ketoconazole | Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases | Terminated | USA | 0 |
NCT03871257 | Phase III | Carboplatin + Vincristine Sulfate Selumetinib | A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma | Recruiting | USA | CAN | 1 |
NCT04544007 | Phase II | Poly ICLC | A Phase II Trial of Poly-ICLC for Low-Grade Gliomas (NF111) | Recruiting | USA | 0 |
NCT04908176 | Phase I | Avapritinib + Midazolam | A Drug-drug Interaction Study of Avapritinib and Midazolam | Active, not recruiting | USA | 0 |