Therapy Detail
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| Therapy Name | Cetrelimab + TAR-200 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cetrelimab | JNJ63723283|JNJ 63723283|JNJ-63723283 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 | Cetrelimab (JNJ-63723283) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28943093). | |
| TAR-200 | GemRIS|TAR 200 | Chemotherapy - Antimetabolite 14 | TAR-200 comprises gemcitabine delivered through an intravesical delivery system that results in gradual release of gemcitabine, which inhibits DNA synthesis and potentially leads to increased tumor cell apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04640623 | Phase II | Cetrelimab + TAR-200 TAR-200 | A Study of TAR-200 in Combination With Cetrelimab, TAR-200 Alone, or Cetrelimab Alone in Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Intravesical Bacillus Calmette-Guerin Who Are Ineligible for or Elected Not to Undergo Radical Cystectomy | Active, not recruiting | USA | NLD | ITA | GRC | GBR | FRA | ESP | DEU | CAN | BEL | AUS | 5 |
| NCT04919512 | Phase II | Cetrelimab + TAR-200 Cetrelimab | A Study of TAR-200 in Combination With Cetrelimab and Cetrelimab Alone in Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder (SunRISe-4) | Recruiting | USA | NLD | ITA | ISR | GBR | FRA | ESP | DEU | BEL | 1 |
| NCT04658862 | Phase III | Cisplatin Cetrelimab + TAR-200 Gemcitabine | A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder | Active, not recruiting | USA | TUR | POL | ITA | HUN | GRC | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG | 9 |
| NCT05714202 | Phase III | BCG solution Cetrelimab + TAR-200 TAR-200 | A Study of TAR-200 in Combination With Cetrelimab or TAR-200 Alone Versus Intravesical Bacillus Calmette-Guérin (BCG) in Participants With BCG-naïve High-risk Non-muscle Invasive Bladder Cancer (SunRISe-3) | Active, not recruiting | USA | POL | NLD | ITA | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BEL | AUS | ARG | 7 |
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