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ID DOID:80877
Name astrocytoma, IDH-mutant, grade 4
Definition An IDH-mutant anaplastic astrocytoma that is characterized by the presence of necrosis and/or microvascular proliferation or homozygous deletion of CDKN2A and/or CDKN2B genes. The term glioblastoma no longer applies to central nervous system WHO grade 4 IDH-mutant astrocytomas.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer cell type cancer high grade glioma malignant astrocytoma anaplastic astrocytoma IDH-mutant anaplastic astrocytoma astrocytoma, IDH-mutant, grade 4

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05917145 Phase I WSD-0628 Clinical Trial of the ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Recurrent Brain Tumors Recruiting USA 0
NCT06047379 Phase Ib/II NEO212 NEO212 + Regorafenib Carboplatin + NEO212 + Paclitaxel Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + NEO212 Ipilimumab + NEO212 NEO212 + Pembrolizumab NEO212 + Nivolumab Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis Recruiting USA 0
NCT06161974 Phase II Olutasidenib + Temozolomide Study of Olutasidenib and Temozolomide in HGG Not yet recruiting USA | NLD | GBR | DEU | CAN | AUS 0
NCT06478212 Phase Ib/II Temozolomide + Vorasidenib Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma Not yet recruiting USA | NLD | ITA | ISR | GBR | FRA | ESP | DEU | AUT 2
NCT06630260 Phase Ib/II Defactinib + RO5126766 + Temozolomide Defactinib + RO5126766 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours (5G-RUBY) Recruiting GBR 0
NCT06632236 Phase I Amivantamab-vmjw 5G-EMERALD: Amivantamab in Malignant Brain Tumours (5G-EMERALD) Recruiting GBR 0