Therapy Detail
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| Therapy Name | AZD1390 |
| Synonyms | |
| Therapy Description |
AZD1390 is a selective inhibitor of ATM that is optimized for blood-brain barrier penetration, thus may preferentially sensitize CNS tumors for radiotherapy (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104, PMID: 29938225, PMID: 31299316). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD1390 | AZD 1390|AZD-1390 | ATM Inhibitor 13 | AZD1390 is a selective inhibitor of ATM that is optimized for blood-brain barrier penetration, thus may preferentially sensitize CNS tumors for radiotherapy (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104, PMID: 29938225, PMID: 31299316). |
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ATM positive | glioblastoma | sensitive | AZD1390 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AZD1390 inhibited Atm activity, sensitized glioblastoma cell lines to radiotherapy in culture, and demonstrated efficacy in mouse models of glioblastoma (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104). | detail... |
| TP53 mutant | glioblastoma | sensitive | AZD1390 | Preclinical - Cell culture | Actionable | In a preclinical study, TP53 mutant glioblastoma cells demonstrated increased sensitivity to radiosensitization by AZD1390 treatment compared to TP53 wild-type cells in culture (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104). | detail... |
| ATM positive | lung cancer | sensitive | AZD1390 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AZD1390 inhibited Atm activity, sensitized lung cancer cells to radiotherapy in culture, and demonstrated efficacy in cell line xenograft models (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04550104 | Phase I | AZD1390 Olaparib | A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC (CONCORDE) | Recruiting | GBR | 0 |
| NCT05116254 | Phase I | AZD1390 + Durvalumab AZD1390 | Sarcomas and DDR-Inhibition; a Combined Modality Study (SADDRIN-1) | Recruiting | NLD | 0 |
| NCT05182905 | Phase I | AZD1390 | Phase 0 Plus Expansion Study of AZD1390 in Recurrent GBM Patients | Recruiting | USA | 0 |
| NCT03423628 | Phase I | AZD1390 | A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer | Recruiting | USA | GBR | 1 |
| NCT05678010 | Phase I | AZD1390 | A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer | Recruiting | USA | 0 |
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