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Therapy Name	AZD1390
Synonyms
Therapy Description	AZD1390 is a selective inhibitor of ATM that is optimized for blood-brain barrier penetration, thus may preferentially sensitize CNS tumors for radiotherapy (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104, PMID: 29938225, PMID: 31299316).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AZD1390		AZD 1390\|AZD-1390	ATM Inhibitor 13	AZD1390 is a selective inhibitor of ATM that is optimized for blood-brain barrier penetration, thus may preferentially sensitize CNS tumors for radiotherapy (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104, PMID: 29938225, PMID: 31299316).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ATM positive	glioblastoma	sensitive	AZD1390	Preclinical - Cell line xenograft	Actionable	In a preclinical study, AZD1390 inhibited Atm activity, sensitized glioblastoma cell lines to radiotherapy in culture, and demonstrated efficacy in mouse models of glioblastoma (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104).	detail...
ATM positive	lung cancer	sensitive	AZD1390	Preclinical - Cell line xenograft	Actionable	In a preclinical study, AZD1390 inhibited Atm activity, sensitized lung cancer cells to radiotherapy in culture, and demonstrated efficacy in cell line xenograft models (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104).	detail...
TP53 mutant	glioblastoma	sensitive	AZD1390	Preclinical - Cell culture	Actionable	In a preclinical study, TP53 mutant glioblastoma cells demonstrated increased sensitivity to radiosensitization by AZD1390 treatment compared to TP53 wild-type cells in culture (Mol Cancer Ther 2018;17(1 Suppl):Abstract nr A104).	detail...

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05678010	Phase I	AZD1390	A Study of AZD1390 and Stereotactic Body Radiotherapy (SBRT) for People With Metastatic Solid Tumor Cancer	Active, not recruiting	USA	0
NCT03423628	Phase I	AZD1390	A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer	Recruiting	USA \| GBR	1
NCT04550104	Phase I	AZD1390 Olaparib	A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC (CONCORDE)	Recruiting	GBR	0
NCT05116254	Phase I	AZD1390 + Durvalumab AZD1390	Sarcomas and DDR-Inhibition; a Combined Modality Study (SADDRIN-1)	Recruiting	NLD	0
NCT05182905	Phase I	AZD1390	Phase 0 Plus Expansion Study of AZD1390 in Recurrent GBM Patients	Recruiting	USA	0
NCT06894979	Phase I	AZD1390	Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma	Recruiting	USA	0

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