Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| ID | DOID:0081250 |
| Name | CIC-rearranged sarcoma |
| Definition | An EWSERI-negative small round cell tumor that is characterized by a recurrent translocation involving the CIC gene on chromosome 19 and either DUX4 gene on chromosome 4 or DUX4L gene on chromosome 10. The translocation results in either CIC-DUX4, t(4;19)(q35;q13) or CIC-DUX4L, t(10;19)(q26;q13) fusions. |
| Source | DiseaseOntology.org |
| Alt Ids | |
| Path | disease disease of cellular proliferation cancer cell type cancer sarcoma small cell sarcoma EWSR1-negative small round cell tumor CIC-rearranged sarcoma |
| Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
|---|
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06414434 | Phase I | BTX-A51 | BTX-A51 in Patients With Liposarcoma or CIC-rearranged Sarcoma | Recruiting | USA | 0 |
| NCT06820957 | Phase II | Irinotecan + Regorafenib + Vincristine Sulfate Cyclophosphamide + Doxorubicin + Etoposide + Ifosfamide + Vincristine Sulfate Cyclophosphamide + Etoposide + Ifosfamide + Vincristine Sulfate | Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body | Active, not recruiting | USA | 0 |
| NCT07089992 | Phase II | Pembrolizumab | A Study of Pembrolizumab in People With Ultra-Rare Sarcomas | Not yet recruiting | USA | 0 |
| NCT07194044 | Phase I | Cyclophosphamide + Topotecan Ifosfamide Cyclophosphamide + Doxorubicin + Vincristine Sulfate Cyclophosphamide + Etoposide Dactinomycin + Ifosfamide + Irinotecan + Vincristine Sulfate Cabozantinib Irinotecan + Temozolomide Pegylated liposomal doxorubicin + Vincristine Sulfate | Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes (METTSEO) | Recruiting | USA | 0 |